What could be learnt from Positronium for Quarkonium?

In order to fulfill Low's theorem requirements, a new lowest order basis for bound state decay computations is proposed, in which the binding energy is treated non-perturbatively. The properties of the method are sketched by reviewing standard positronium decay processes. Then, it is shown how applying the method to quarkonia sheds new light on some longstanding puzzles.Comment: 12 pages, 10 figures. Talk given at the ETH Workshop on Positronium Physics, May 30-31, 2003, Zurich, Switzerlan

A Massive Yang-Mills Theory based on the Nonlinearly Realized Gauge Group

We propose a subtraction scheme for a massive Yang-Mills theory realized via a nonlinear representation of the gauge group (here SU(2)). It is based on the subtraction of the poles in D-4 of the amplitudes, in dimensional regularization, after a suitable normalization has been performed. Perturbation theory is in the number of loops and the procedure is stable under iterative subtraction of the poles. The unphysical Goldstone bosons, the Faddeev-Popov ghosts and the unphysical mode of the gauge field are expected to cancel out in the unitarity equation. The spontaneous symmetry breaking parameter is not a physical variable. We use the tools already tested in the nonlinear sigma model: hierarchy in the number of Goldstone boson legs and weak power-counting property (finite number of independent divergent amplitudes at each order). It is intriguing that the model is naturally based on the symmetry SU(2)_L local times SU(2)_R global. By construction the physical amplitudes depend on the mass and on the self-coupling constant of the gauge particle and moreover on the scale parameter of the radiative corrections. The Feynman rules are in the Landau gauge.Comment: 44 pages, 1 figure, minor changes, final version accepted by Phys. Rev.

Quark-hadron duality, axial anomaly and mixing

Interplay between axial anomaly and quark-hadron duality in the presence of strong mixing is considered. The anomaly sum rule for meson transition form factors based on the dispersive representation of axial anomaly and quark-hadron duality in octet channel is analyzed. The comparison of this sum rule to the experimental data on $\eta$ and $\eta'$ mesons transition form factors shows that the interval of duality in this channel is rather small, contradicting the usual understanding of quark-hadron duality. The same values of interval of duality are supported by considering the two-point correlator in the local duality limit. This contradiction may be resolved by introducing of some nonperturbative non-OPE correction to the relevant spectral density. The form and value of this correction are discussed.Comment: 9 pages, 1 figure, reference adde

Two photon decay of the pseudoscalars, the chiral symmetry breaking corrections

The extrapolation of the decay amplitudes of the pseudoscalar mesons into two photons from the soft meson limit where it is obtained from the axial-anomaly to the mass shell involves the contribution of the 0^ - continuum. These chiral symmetry breaking corrections turn out to be large. The effects of these corrections on the calculated pi ^0 decay rate, on the values of the singlet-octet mixing angle and on the ratios f_8 / f_pi and f_0 / f_pi are discussed. The implications for the transition form factors gamma gamma* --> pseudoscalars are also evaluated and confronted with the available experimental data.Comment: Computational errors straightened and study of the implications on the form factors of the transitions gamma gamma* --> pseudoscalars adde

Symmetry preserving regularization with a cutoff

A Lorentz and gauge symmetry preserving regularization method is proposed in 4 dimension based on momentum cutoff. We use the conditions of gauge invariance or freedom of shift of the loop-momentum to define the evaluation of the terms carrying Lorentz indices, e.g. proportional to k_{\mu}k_{\nu}. The remaining scalar integrals are calculated with a four dimensional momentum cutoff. The finite terms (independent of the cutoff) are unambiguous and agree with the result of dimensional regularization.Comment: 12 pages, 1 figure, v2 references adde

The Higgs resonance in vector boson scattering

A heavy Higgs resonance is described in a representation-independent way which is valid for the whole energy range of 2 -> 2 scattering processes, including the asymptotic behavior at low and high energies. The low-energy theorems which follow from to the custodial SU_2 symmetry of the Higgs sector restrict the possible parameterizations of the lineshape that are consistent in perturbation theory. Matching conditions are specified which are necessary and sufficient to relate the parameters arising in different expansions. The construction is performed explicitly up to next-to-leading order.Comment: 25 pages, revtex, uses epsf, amssym

The effects of violence and aggression from parents on child protection workers' personal, family and professional lives

Creative Commons CC-BY: This article is distributed under the terms of the Creative Commons Attribution 3.0 License (http://www.creativecommons.org/licenses/by/3.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).This article presents findings from a survey of the experiences of child protection workers in England when working with parents who exhibit aggression and violence. This work explores the effects on workers in their professional lives, and on themselves and their families in their private lives. The article examines workers’ thoughts and experiences about the effects of parental hostility on workers’ ability to protect children. The article also details workers’ experiences of the nature and effectiveness of training and support in this area. These findings are then examined in the light of the results of an analysis of the literature, including the findings from serious case review (SCR) reports in England (official inquiries into the causes of child deaths where the children are known to social and health services). The majority of the 590 respondents in the survey were social workers (n = 402; 68%), reflecting the fact that case management of child protection cases in the United Kingdom is the responsibility of social workers working in statutory agencies. This article addresses, from a consideration of the secondary analysis and the original research findings from the survey, how individual workers, managers, and agencies can best understand and then respond effectively to aggressive parental behaviors.Peer reviewe

Apolipoprotein E gene is related to mortality only in normal weight individuals: The Rotterdam study

Objective To investigate the relationship between the apolipoprotein E (APOE) gene and the risk of mortality in normal weight, overweight and obese individuals. Methods and Results In a population-based study of 7,983 individuals aged 55 years and older, we compared the risks of all-cause and coronary heart disease (CHD) mortality by APOE genotype, both overall and in subgroups defined by body mass index (BMI). We found significant evidence for interaction between APOE and BMI in relation to total cholesterol (p = 0.04) and HDL cholesterol (p < 0.001). Overall, APOE*2 carriers showed a decreased risk of all-cause mortality. Analyses within BMI strata showed a beneficial effect of APOE*2 only in normal weight persons (adjusted hazard ratio (HR) 0.7[95% CI 0.5–0.9]). APOE*2 was not associated with a lower risk of all-cause mortality in overweight or obese persons. The effect of APOE*2 in normal weight individuals tended to be due to the risk of CHD mortality (adjusted HR 0.5 [95% CI 0.2–1.2]). Conclusion The APOE*2 allele confers a lower risk of all-cause mortality only to normal weight individuals

Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility

<p>Abstract</p> <p>Background</p> <p>Increased hemostatic activity is common in many cancer types and often causes additional complications and even death. Circumstantial evidence suggests that tissue factor pathway inhibitor-1 (TFPI) plays a role in cancer development. We recently reported that downregulation of TFPI inhibited apoptosis in a breast cancer cell line. In this study, we investigated the effects of TFPI on self-sustained growth and motility of these cells, and of another invasive breast cancer cell type (MDA-MB-231).</p> <p>Methods</p> <p>Stable cell lines with TFPI (both α and β) and only TFPIβ downregulated were created using RNA interference technology. We investigated the ability of the transduced cells to grow, when seeded at low densities, and to form colonies, along with metastatic characteristics such as adhesion, migration and invasion.</p> <p>Results</p> <p>Downregulation of TFPI was associated with increased self-sustained cell growth. An increase in cell attachment and spreading was observed to collagen type I, together with elevated levels of integrin α2. Downregulation of TFPI also stimulated migration and invasion of cells, and elevated MMP activity was involved in the increased invasion observed. Surprisingly, equivalent results were observed when TFPIβ was downregulated, revealing a novel function of this isoform in cancer metastasis.</p> <p>Conclusions</p> <p>Our results suggest an anti-metastatic effect of TFPI and may provide a novel therapeutic approach in cancer.</p